Outcomes of primary CNS lymphoma treated with combined immunochemotherapy with whole-brain radiotherapy
Our study demonstrates that contemporary HD-MTX-based chemoimmunotherapy induction regimens achieve good disease responses in PCNSL. We also highlight significant prognostic factors and a potential role for immunotherapy in PCNSL.
Authors
- Ryan Mao Heng Lim (ORCID: https://orcid.org/0000-0002-3348-1037)
- Muhammad Taib
- Soon Thye Lim (ORCID: https://orcid.org/0000-0002-0366-5505)
- Jason Yongsheng Chan (ORCID: https://orcid.org/0000-0002-4801-3703)
- Jing Yuan Tan (ORCID: https://orcid.org/0000-0001-5770-4701)
- Boon Yee Lim
- Choon Kiat Ong (ORCID: https://orcid.org/0000-0001-6402-4288)
- Chee Leong Cheng (ORCID: https://orcid.org/0000-0002-2140-4827)
- Ya Hwee Tan (ORCID: https://orcid.org/0000-0002-9442-4511)
- Kheng Wei Yeoh
- Nur Ayuni Binte
Institutions
- Singapore General Hospital (SG)
- SingHealth Duke-NUS Academic Medical Centre (SG)
- Duke-NUS Medical School (SG)
- National Cancer Centre Singapore (SG)
Publication Details
- Journal
- Annals of Hematology
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1007/s00277-025-06561-1
- Primary Topic
- CNS Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Duke-NUS Medical School
- Tanoto Foundation
- Medical Research Council
- National Medical Research Council