Novel Sulfonamide Derivatives as Anticancer Agents, VEGFR-2 Inhibitors, and Apoptosis Triggers: Design, Synthesis, and Computational Studies
Compounds <b>3a</b>, <b>6</b>, and <b>15</b> represent promising VEGFR-2-targeting sulfonamides with potent, selective anticancer activity and favorable pharmacokinetic and safety profiles, warranting further development as lead candidates.
Authors
- Ahmed H. Halawa (ORCID: https://orcid.org/0000-0002-4860-5768)
- Amany Belal (ORCID: https://orcid.org/0000-0003-1045-0163)
- Walid E. Elgammal (ORCID: https://orcid.org/0000-0002-5982-5635)
- Ahmed B. M. Mehany
- N.S. Abdelshafi (ORCID: https://orcid.org/0000-0001-5170-1745)
- Ahmad J. Obaidullah (ORCID: https://orcid.org/0000-0002-7532-6318)
- Shatha Hallal Al-Ziyadi
- Hossa F. Al-Shareef
- Saber M. Hassan
- Nisreen Khalid Aref Albezrah
Institutions
- Ain Shams University (EG)
- Boys Town (US)
- Taif University (SA)
- Al-Azhar University (EG)
- Umm al-Qura University (SA)
- King Saud University (SA)
- Al-Azhar University (ID)
- American Congress of Obstetricians and Gynecologists (US)
Publication Details
- Journal
- ACS Omega
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1021/acsomega.5c03503
- Citations
- 4
- Primary Topic
- Enzyme function and inhibition
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Taif University