Multi-population genome-wide association study identifies multiple novel loci associated with asymptomatic intracranial large artery stenosis
This study reveals one variant rs75615271 and a gene-set enriched in chr1q32 region associated with asymptomatic ILAS in a multi-population. Further functional studies may help elucidate the role that this variant plays in the pathophysiology of asymptomatic ILAS.
Authors
- Howard Andrews (ORCID: https://orcid.org/0000-0002-7726-0551)
- Giuseppe Tosto (ORCID: https://orcid.org/0000-0001-7075-8245)
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Mitchell S.V. Elkind (ORCID: https://orcid.org/0000-0003-2562-1156)
- Christopher Chen (ORCID: https://orcid.org/0000-0002-1047-9225)
- Tatjana Rundek (ORCID: https://orcid.org/0000-0002-7115-9815)
- Jose Rafael Romero (ORCID: https://orcid.org/0000-0002-1101-2950)
- Bruce A. Wasserman (ORCID: https://orcid.org/0000-0001-8458-1778)
- Antonio Spagnolo‐Allende (ORCID: https://orcid.org/0000-0001-6057-4469)
- Danurys Sanchez (ORCID: https://orcid.org/0000-0001-8273-0952)
- Saima Hilal (ORCID: https://orcid.org/0000-0001-5434-5635)
- Minghua Liu (ORCID: https://orcid.org/0000-0003-3197-6068)
- José Gutierrez (ORCID: https://orcid.org/0000-0002-2175-8078)
- Jennifer J. Manly (ORCID: https://orcid.org/0000-0002-9481-7497)
- Óscar H. Del Brutto (ORCID: https://orcid.org/0000-0003-1917-8805)
- Farid Khasiyev (ORCID: https://orcid.org/0000-0002-3127-0973)
- Myriam Fornage (ORCID: https://orcid.org/0000-0003-0677-8158)
- Qiong Yang
- Ye Qiao
- Alexa S. Beiser
- Adam M Brickman
Institutions
- Boston University (US)
- University of Maryland, Baltimore (US)
- University of Minnesota (US)
- Johns Hopkins University (US)
- University of Miami (US)
- National University of Singapore (SG)
- The University of Texas at San Antonio Health Science Center (US)
- Johns Hopkins Medicine (US)
- Universidad Espíritu Santo (EC)
- Institute for Neurodegenerative Disorders (US)
- Brown Foundation (US)
- Saint Louis University (US)
- Columbia University (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- International Journal of Stroke
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1177/17474930251374471
- Citations
- 2
- Primary Topic
- Cerebrovascular and Carotid Artery Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- American Heart Association
- National Institutes of Health
- National Medical Research Council
- National Heart, Lung, and Blood Institute
- National Human Genome Research Institute