Case Report: Acute polymorphic psychosis and NMDA-R IgG antibodies in serum: a follow-up case study
The international consensus criteria for a probable/definite diagnosis of NMDA-R encephalitis or autoimmune psychosis were not fulfilled, especially as no NMDA-R IgG antibodies were identified in CSF using different antibody assays and EEG/CSF routine findings were inconspicuous. NMDA-R encephalitis was therefore not diagnosed (as initially suspected). Independent of the NMDA-R IgG antibodies, there were possible signs of an autoimmune process. For a better understanding of similar patients, multimodal diagnostic approaches including complementary antibody tests could be promising.
Authors
- Bernd Feige (ORCID: https://orcid.org/0000-0002-9436-1258)
- Katharina Domschke (ORCID: https://orcid.org/0000-0002-2550-9132)
- Nils Venhoff (ORCID: https://orcid.org/0000-0001-7729-2759)
- Katharina von Zedtwitz
- Ludger Tebartz van Elst (ORCID: https://orcid.org/0000-0002-2274-5447)
- Harald Prüß (ORCID: https://orcid.org/0000-0002-8283-7976)
- Luciana Hannibal (ORCID: https://orcid.org/0000-0002-0911-5758)
- Jessica A. Weiser
- Simon Maier (ORCID: https://orcid.org/0000-0002-4285-8174)
- Raphael J. Dressle (ORCID: https://orcid.org/0000-0001-9408-5196)
- Joachim Brumberg (ORCID: https://orcid.org/0000-0003-0959-4776)
- Dominique Endres (ORCID: https://orcid.org/0000-0001-7322-1195)
- Kathrin Nickel (ORCID: https://orcid.org/0000-0001-9863-317X)
- Alexander Rau (ORCID: https://orcid.org/0000-0001-5881-6043)
- Sebastian Rauer (ORCID: https://orcid.org/0000-0002-9889-078X)
Institutions
- University Medical Center Freiburg (DE)
- German Center for Neurodegenerative Diseases (DE)
- German Centre for Cardiovascular Research (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-25
- DOI
- https://doi.org/10.3389/fimmu.2025.1630357
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Albert-Ludwigs-Universität Freiburg
- European College of Neuropsychopharmacology
- Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg