Association of cord blood vitamin D and genetic polymorphisms with childhood food allergy in Shanghai, China: a prospective cohort
Genetic susceptibility in Th2 pathway genes (IL4R, IL-4, IL13) dramatically amplified food allergy risk under vitamin D deficiency, with AA/GG/CC genotypes conferring 4- to 26-fold increased susceptibility. Conversely, the protective effect of MS4A2 rs569108 GG genotype was compromised at high vitamin D levels (>25 ng/mL). Our findings underscore that personalized vitamin D thresholds during pregnancy must account for fetal genetic background to mitigate allergy risk.
Authors
- Xiaodan Yu
- Yingying Cai (ORCID: https://orcid.org/0000-0001-5020-0906)
- Bin Wang (ORCID: https://orcid.org/0000-0002-4869-1352)
- Jun Zhang (ORCID: https://orcid.org/0000-0003-1706-1611)
- Ying Tian (ORCID: https://orcid.org/0000-0003-3225-7962)
- Jingjing Pei
- Xirui Wang (ORCID: https://orcid.org/0000-0001-6260-3630)
Institutions
- Jiangnan University (CN)
- XinHua Hospital (CN)
- Fujian Women and Children Hospital (CN)
- Shanghai Children's Medical Center (CN)
- Jiangxi Maternal and Child Health Hospital (CN)
- Shanghai Children's Hospital (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-08-25
- DOI
- https://doi.org/10.3389/fnut.2025.1652487
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Projects of Fujian Province
- Shanghai Jiao Tong University
- School of Medicine, Shanghai Jiao Tong University
- National Key Research and Development Program of China