Inter-species and individualized biotransformation of five saponins by human being- and mouse-derived fecal microbiota
This study elucidated the pivotal role of gut microbiota in mediating inter-individual differences in saponin biotransformation, while having identified potential microbial communities and metabolic pathways involved in saponin biotransformation. These findings not only advance understanding of species-dependent biotransformation of saponins but also establish a foundation for screening microbial strains or enzymes to optimize saponin-derived therapies, thereby facilitating precision medicine and translational research.
Authors
- Mingxiao Li (ORCID: https://orcid.org/0000-0003-1295-6811)
- Houkai Li (ORCID: https://orcid.org/0000-0003-2846-7895)
- Xiaofang He
- Ningning Zheng (ORCID: https://orcid.org/0000-0003-0394-0711)
- Wenjing Wei (ORCID: https://orcid.org/0000-0002-4990-3580)
- Yuanyuan Li (ORCID: https://orcid.org/0000-0002-9143-8029)
- Lili Sheng (ORCID: https://orcid.org/0000-0002-1142-6512)
- M. Shao
- Lingyun Pan
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Children's Hospital (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1186/s13020-025-01190-2
- Citations
- 4
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China