Multi-omics analysis reveals ACOT1 as the key target of piperine in Piper Longum-mediated gastric cancer treatment
This study elucidates Piper longum's "component-target-pathway" mechanism in GC treatment, highlighting piperine-ACOT1-de novo lipogenesis regulatory pathway as a critical axis. Additionally, it establishes a robust multi-omics framework for evaluating traditional medicine efficacy, providing a theoretical foundation for Piper longum's clinical application in GC therapy.
Authors
- Zeyang Liu (ORCID: https://orcid.org/0009-0007-5205-0279)
- Xiaofeng Wang (ORCID: https://orcid.org/0000-0001-8524-6488)
- Chunnuan Wu (ORCID: https://orcid.org/0009-0001-8196-4463)
- Liren Liu (ORCID: https://orcid.org/0000-0001-7786-7874)
- Runfang Wang (ORCID: https://orcid.org/0000-0003-2775-8893)
- Ling Liu
- Jie Zhang
- Rui Li (ORCID: https://orcid.org/0000-0001-5953-2341)
- Xiaoyan Li (ORCID: https://orcid.org/0000-0001-6554-6811)
- Boyu Pan
- Bao Jin (ORCID: https://orcid.org/0000-0002-7488-8204)
Institutions
- Shanxi Medical University (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Inner Mongolia People's Hospital (CN)
- Inner Mongolia International Mongolian Hospital (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1186/s13020-025-01186-y
- Citations
- 1
- Primary Topic
- Piperaceae Chemical and Biological Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.56
Funders
- National Natural Science Foundation of China
- Tianjin Medical University