CURRENT TRENDS IN ANTIMICROBIAL SUSCEPTIBILITY PATTERNS OF ESCHERICHIA COLI ISOLATES AT BACHA KHAN MEDICAL COMPLEX SWABI,KPK, PAKISTAN

Background: Escherichia coli (E. coli) is a gram negative bacterium resembling to rod shape that associated with Urinary tract infection, Blood stream infection and sepsis as well. Globally E coli are the primary pathogen which is associated with cause of both community- and hospital-acquired infections worldwide. The prevalence of antibiotic resistance increased with misused of antibiotic in our country. Objective: This research aimed to analyze the current trends of antimicrobial resistance pattern of E coli isolate in various samples including Urine, Pus and Blood. Method: This was a cross sectional study conducted from September to December 2024 in the microbiology section of pathology department. We collected 288 samples of blood, urine and pus from different patients in sterile bottle and antimicrobial susceptibility was examined using clinical Laboratory standards Institute (CLSI) guidelines. Results: Nitrofurantoin (100%) and Amikacin (96.9%) were the highest sensitive antibiotics among those isolated in urine Culture, while Ampicillin (100%) was the most resistant. For Blood isolates Imipenem, Meropenem, and Piperacillin Tazobactam (100%) these all are the most effective antibiotics while ampicillin and cefazolin were highest resistant. And For Pus isolates Meropenem and Gentamycin are the most effective antibiotics with sensitivity (94.1%) while ampicillin and cefazolin (100%) show highest resistant. Conclusion: This study concludes that 48% of isolates yielded the growth of E Coli among the different types of samples include, Urine, Blood, and Pus. The antibiotic pattern shows that in Urine: the most effective antibiotic is Nitrofurantoin and most resistant is ampicillin. In blood Meropenem and imipenem has highest sensitivity while Cefazolin, Cefoxitin, and ceftriaxone shows highest resistivity. In case of Pus Gentamycin and Meropenem show highest effective drugs and Ampicillin, and cefazolin is highest resistant drugs.