Potential impact of omentin-1 genetic variants on perineural invasion in prostate cancer
One of the most prevalent cancers and a major global cause of mortality in men is prostate cancer (PCa). Omentin-1, an adipokine, has been shown to play a protective role by reducing proinflammatory cytokine secretion. The relationships among carcinogenic lifestyle factors, biochemical recurrence (BCR), <i>OMNT1</i> polymorphisms, and PCa remain unclear. We investigated the impact of clinicopathological features and four <i>OMNT1</i> gene variants on PCa risk in 701 Taiwanese male patients with and without BCR. Compared with the TT genotype, the TA+AA genotypes of SNP rs2274907 were associated with a lower risk of perineural invasion. Similarly, the AG+GG genotypes of rs4656959 were associated with a lower risk of perineural invasion compared to the AA genotype. Importantly, PCa patients without BCR exhibited the same effects. Interestingly, the wild-type TT homozygous genotype was associated with significantly lower <i>OMNT1</i> expression levels compared to the AA genotype of the rs2274907 variant. Additionally, <i>OMNT1</i> mRNA levels were lower in PCa tissues compared to normal tissues, indicating that omentin-1 acts as a protective factor in PCa.
Authors
- Yuan‐Li Huang (ORCID: https://orcid.org/0000-0002-3405-8863)
- Xiu-Yuan He
- Shun‐Fa Yang (ORCID: https://orcid.org/0000-0002-0365-7927)
- Chia‐Yen Lin (ORCID: https://orcid.org/0000-0002-6303-2187)
- Chun‐Hao Tsai (ORCID: https://orcid.org/0000-0002-4428-3132)
- Hsi‐Chin Wu (ORCID: https://orcid.org/0000-0001-7409-3295)
- Chao-Yang Lai (ORCID: https://orcid.org/0000-0002-7929-9804)
- Chih‐Hsin Tang (ORCID: https://orcid.org/0000-0002-7113-8352)
- Wei‐Chun Weng (ORCID: https://orcid.org/0000-0002-8844-4882)
- Yi‐Chin Fong
- Tien-Huang Lin
Institutions
- Asia University (TW)
- National Yang Ming Chiao Tung University (TW)
- National Chung Hsing University (TW)
- China Medical University (TW)
- Tzu Chi University (TW)
- Taichung Veterans General Hospital (TW)
- Chung Shan Medical University Hospital (TW)
- China Medical University Beigang Hospital (TW)
- Buddhist Tzu Chi General Hospital (TW)
- China Medical University Hospital (TW)
- Tungs' Taichung MetroHarbor Hospital (TW)
- Kang-Ning Junior College of Medical Care and Management (TW)
- Chung Shan Medical University (TW)
- National Yang Ming Chiao Tung University (TW)
Publication Details
- Journal
- Journal of Cancer
- Published
- 2025-08-11
- DOI
- https://doi.org/10.7150/jca.119089
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Medical University Hospital
- China Medical University
- National Science and Technology Council
- Division of Materials Research