Neonatal hypercalcemia due to subcutaneous fat necrosis caused by therapeutic hypothermia in a newborn

Subcutaneous fat necrosis (SCFN) is a rare inflammatory disorder of unknown pathogenesis of adipose tissue that occurs in the first few weeks of life, its clinical findings usually regress spontaneously, accompanied by severe systemic findings such as hypercalcemia, thrombocytopenia, and hypertriglyceridemia. It presents with painless and sharply circumscribed nodules or plaques. It is panniculitis that can be seen frequently on the face, neck, back and proximal extremities. Perinatal complications such as gestational diabetes, preeclampsia, asphyxia, meconium aspiration, birth trauma, sepsis and hypothermia are risk factors. Here, we present a newborn with a diagnosis of stage 2 hypoxic ischemic encephalopathy who was sent to our hospital due to asphyxic delivery and received cooling therapy for 72 hours with mild hypercalcemic findings and SCFN.