Association of serum cyclooxygenase-2 levels with hand-foot syndrome in patients receiving capecitabine: an exploratory analysis of D-TORCH study
Serum COX-2 levels did not show a significant change with capecitabine-based therapy, regardless of the use of topical diclofenac possibly reflecting the predominant stromal production of the enzyme. This finding highlights the need to assess HFS-affected tissues for local COX-2 immuno-expression along with further blood-based biomarkers.
Authors
- Sameer Bakhshi (ORCID: https://orcid.org/0000-0001-9367-4407)
- Ishaan Gupta (ORCID: https://orcid.org/0000-0001-8934-9919)
- Pranay Tanwar (ORCID: https://orcid.org/0000-0002-2357-976X)
- Ghazal Tansir (ORCID: https://orcid.org/0000-0002-1045-7771)
- Mohit Kumar Divakar (ORCID: https://orcid.org/0000-0002-6731-9249)
- Saran Kumar (ORCID: https://orcid.org/0000-0002-5052-0499)
- Akhil Santhosh (ORCID: https://orcid.org/0000-0001-6780-0406)
- Chandra Prakash Prasad (ORCID: https://orcid.org/0000-0002-4911-7483)
- Atul Batra (ORCID: https://orcid.org/0000-0002-1934-8408)
- Apurva Dev
- Akash Kumar (ORCID: https://orcid.org/0000-0001-9442-3597)
- Hemavathi Baskarane (ORCID: https://orcid.org/0000-0003-0946-8518)
- Atul Sharma (ORCID: https://orcid.org/0000-0003-2627-5814)
- Vishakha Hooda
Institutions
- Metropolitan University (BD)
- All India Institute of Medical Sciences (IN)
- Indian Institute of Technology Delhi (IN)
Publication Details
- Journal
- ecancermedicalscience
- Published
- 2025-08-15
- DOI
- https://doi.org/10.3332/ecancer.2025.1967
- Primary Topic
- Chemotherapy-related skin toxicity
- Type
- article
- Field-Weighted Citation Impact
- 0.00