Breaking the Paradigm: Successful Treatment of Rare CD4/CD8 Dual-Positive, Advanced Mycosis Fungoides Using CHOP Therapy

Mycosis fungoides (MF) is one of the most important representatives of cutaneous T-cell lymphomas. This disease is rare, and the diagnosis always requires a clinical-pathological correlation. The prognosis depends on its stage and is usually favorable when found in early stages. CD4/CD8 duality is an uncommon immune phenotype. We are presenting a successful treatment of a case of dual-positive MF in the third stage. The simultaneous expression of CD4 and CD8 in skin lesions has been suggested to potentially indicate an improved clinical outcome in patients with MF. Patient was treated with the CHOP regimen and a combination of symptomatic therapies, which resulted in a favorable therapeutic response.