Role of lncRNA <i>MGP202</i> in Modulating B Cell Dynamics and Its Implications in Ulcerative Colitis
Our study reveals the upregulation of MGP202 in UC patients and its regulation of B cell proliferation through sponging hsa-miR-5590-3p and modulating IL-33 expression. These findings highlight MGP202 as a potential diagnostic and therapeutic target for UC, particularly in the context of B cell dynamics. Further investigations are warranted to evaluate clinical applicability and unravel additional mechanisms related to MGP202 modulation of B cell behavior in UC.
Authors
- Xiaoyin Bai (ORCID: https://orcid.org/0000-0002-9092-7592)
- Yang Liu (ORCID: https://orcid.org/0000-0003-4874-4773)
- Mingyue Guo (ORCID: https://orcid.org/0000-0002-3582-446X)
- Xuyang Dong (ORCID: https://orcid.org/0000-0002-0397-739X)
- Hong Yang (ORCID: https://orcid.org/0000-0002-2986-7324)
- Dongdong Zhang (ORCID: https://orcid.org/0009-0008-0861-0926)
- Qian Jiaming (ORCID: https://orcid.org/0000-0002-6252-7022)
- Yashu Zhu
- Runing Zhou
- Meixu Wu
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Institute of Biophysics (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2025-07-25
- DOI
- https://doi.org/10.1093/ibd/izaf176
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality