Impact of omega-3 supplementation on inflammatory markers and clinical outcomes in patients with moderate-to-severe head injuries: An experimental trial

Omega-3 supplementation significantly reduced inflammatory markers and oxidative stress in patients with moderate-to-severe head injuries. However, it did not improve long-term clinical outcomes as measured by GOS-E scores, indicating the need for further studies to explore optimal dosing, composition (particularly high-DHA formulations), magnesium status, and long-term effects of omega-3 therapy in head injury recovery.

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Publication Details

Journal
Surgical Neurology International
Published
2025-08-15
DOI
https://doi.org/10.25259/sni_444_2025
Primary Topic
Traumatic Brain Injury and Neurovascular Disturbances
Type
article
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article

Impact of omega-3 supplementation on inflammatory markers and clinical outcomes in patients with moderate-to-severe head injuries: An experimental trial

I Wayan Niryana, Joshua Sutikno, I Gusti Ketut Agung Surya Kencana, Tjokorda Gde Bagus Mahadewa
Surgical Neurology International
Traumatic Brain Injury and Neurovascular Disturbances
article

Impact of omega-3 supplementation on inflammatory markers and clinical outcomes in patients with moderate-to-severe head injuries: An experimental trial

I Wayan Niryana, Joshua Sutikno, I Gusti Ketut Agung Surya Kencana, Tjokorda Gde Bagus Mahadewa
article en

Abstract

Omega-3 supplementation significantly reduced inflammatory markers and oxidative stress in patients with moderate-to-severe head injuries. However, it did not improve long-term clinical outcomes as measured by GOS-E scores, indicating the need for further studies to explore optimal dosing, composition (particularly high-DHA formulations), magnesium status, and long-term effects of omega-3 therapy in head injury recovery.

Surgical Neurology InternationalVol. 16
Udayana University (ID)
Openalex Percentile: Top 68%
Traumatic Brain Injury and Neurovascular Disturbances
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