Intelligent Chemical Synthesis in an Undergraduate Teaching Laboratory: Continuous Flow Synthesis of S<sub>N</sub>Ar Reaction with Automated Robot-Assisted Condition Screening
An integrated undergraduate teaching laboratory experiment was developed by applying an automated robot, a 48-well plate, and continuous flow chemistry in a typical SNAr reaction. This experiment involved the concepts of green chemistry, homogeneous reaction, continuous flow chemistry and intelligent chemistry, encouraging students to determine the optimal flow synthesis conditions independently. By engaging in this experiment, students gain hands-on experience with modern chemical engineering practices and learn to appreciate the efficiency and sustainability of continuous flow processes.
Authors
- Fujun Li (ORCID: https://orcid.org/0009-0009-2888-4841)
- L. Zhong (ORCID: https://orcid.org/0000-0002-1281-5077)
- Wenjun Xu (ORCID: https://orcid.org/0000-0002-0053-0752)
- Shengyang Tao (ORCID: https://orcid.org/0000-0002-0567-8860)
- Wenbo Yang (ORCID: https://orcid.org/0000-0003-2156-0560)
- Lijing Zhang (ORCID: https://orcid.org/0000-0003-1126-8785)
- Haiyang Wang
- Wenfeng Jiang (ORCID: https://orcid.org/0009-0008-2575-4171)
Institutions
- Dalian University of Technology (CN)
- Dalian University (CN)
- Smart Material (Germany) (DE)
- State Key Laboratory of Fine Chemicals
Publication Details
- Journal
- Journal of Chemical Education
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1021/acs.jchemed.4c01072
- Citations
- 2
- Primary Topic
- Innovative Microfluidic and Catalytic Techniques Innovation
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Natural Science Foundation of China
- Dalian University of Technology
- Fundamental Research Funds for the Central Universities