Pharmaceutical and Analytical Assessment of Jadamayadi Transdermal Pain Patch: An in-vitro Study on Development, Evaluation and optimization

The present study focuses on the pharmaceutical and analytical assessment of Jadamayadi transdermal pain patch through an in vitro approach for its development, evaluation, and optimization. Jadamayadi choorna, a classical Ayurvedic formulation known for its analgesic and anti-inflammatory properties, was incorporated into a transdermal patch system to enhance its therapeutic efficacy and patient compliance. Preparation of the transdermal patches polymer base by dissolving the selected polymer (HPMC and PVA) in a solvent like water or ethanol, and evaluated for physicochemical parameters including thickness, weight uniformity, folding endurance, moisture content, moisture uptake, drug content, and surface pH. The in vitro anti-arthritic activity is evaluated using the protein denaturation inhibition assay, phytochemicals analysis done by LC-MS technique. The formulation was optimized based on evaluation parameters to achieve desirable mechanical properties and sustained drug release. The study shows the anti-inflammatory, antiarthritic, analgesics property and the potential of Jadamayadi transdermal pain patch as a novel, effective, and non-invasive alternative for pain management, aligning traditional medicine with modern pharmaceutical technologies. Key words: Anti-inflammatory, Anti-arthritic, Analgesics property, Pain patch