Impact of advanced therapies on surgical recurrence following second ileocolic resection in Crohn’s disease

Following second surgery, the 5-year third surgery rate is 12.1%, which has remained stable over the past two decades. No statistically significant reduction in third surgery rates were observed in patients receiving prophylactic advanced therapies. This may reflect both the predominantly stricturing disease as indication for redo surgery, which is typically less amenable to medical treatment, and the shorter follow-up in C2.