Optimisation of Sub-30 nm Solid Lipid Nanoparticles Loaded With Docetaxel Produced by the Cold-Burst Method: A Particle Size Optimisation Study

These findings highlight the potential of cold-burst-derived sub-30 nm SLNs as an optimised platform. Our work demonstrates the successful optimisation of particle size for DTX-loaded SLNs, laying a foundation for future comprehensive studies towards enhanced DTX delivery and more effective cancer therapeutics. However, the absence of drug loading quantification, in vitro drug release data, and cellular performance assessments limits the conclusions regarding the therapeutic efficacy of these SLNs.