Multidimensional characterization and clinical profiling of subchondral bone endotypes in hip osteoarthritis
The consideration of subchondral bone endotypes may enable a personalized approach to the treatment of hip OA. Based on the respective cluster, subchondral homeostasis may be restored through targeted interventions, including the modulation of bone turnover, osteocytes, or bone marrow adipocytes, tailored to each endotype's unique profile, thereby laying the foundation for disease-modifying therapies.
Authors
- Jeroen Geurts (ORCID: https://orcid.org/0000-0002-4367-4641)
- Ana Ocokoljic (ORCID: https://orcid.org/0009-0001-2567-5747)
- Johannes Keller (ORCID: https://orcid.org/0000-0002-8925-7288)
- Assil‐Ramin Alimy (ORCID: https://orcid.org/0000-0002-2013-4212)
- Tim Rolvien (ORCID: https://orcid.org/0000-0003-1058-1307)
- Frank Timo Beil (ORCID: https://orcid.org/0000-0001-7965-1946)
- Eva Goedecke
- Julian Delsmann
- Julius Rosenfeld
- Maximilian Möhlmann
Institutions
- Universität Hamburg (DE)
- Centre Hospitalier Universitaire Vaudois (CH)
- University Medical Center Hamburg-Eppendorf (DE)
- University of Lausanne (CH)
Publication Details
- Journal
- Osteoarthritis and Cartilage
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1016/j.joca.2025.08.011
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00