Rad6 and Bre1 ubiquitin ligase negatively regulate biofilm formation and virulence in Candida glabrata
Rad6 and Bre1 in C. glabrata function as negative regulators of biofilm formation and adhesion, and their related-genes expression, while RAD6 deletion also suppresses macrophage ROS production and enhances fungal survival. The enhanced virulence observed in the rad6 and bre1 mutants is primarily attributed to these combined effects of increased biofilm formation, enhanced adhesion capability, and macrophage immune evasion.
Authors
- Kai-Quan Leong
- Ying‐Lien Chen (ORCID: https://orcid.org/0000-0002-1966-470X)
- Li-Hang Hsu
- Hao-Sen Chiang (ORCID: https://orcid.org/0000-0001-5041-9705)
- Yi-Hang Lee
- Zhu Yu
Institutions
- National Taiwan University of Science and Technology (TW)
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
Publication Details
- Journal
- Journal of Infection
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1016/j.jinf.2025.106595
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Taiwan University
- National Science and Technology Council