Uncommon Manifestations of Newly Diagnosed B-cell Chronic Lymphocytic Leukemia Prompting the Concurrent Diagnosis of Advanced Prostate Cancer: A Case Report

Patients with chronic lymphocytic leukemia (CLL) have an increased risk for developing secondary malignancies (SMs), which usually follow an aggressive clinical course and are associated with unfavorable survival rates. Herein, we describe a patient diagnosed with CLL, who also presented with uncommon findings such as extremely elevated alkaline phosphatase levels, abnormal coagulation studies, and leucoerythroblastic reaction, that ultimately resulted in the diagnosis of concurrent metastatic prostate cancer. Early recognition of findings indicative of SM in CLL patients, even during early stages, is crucial, and physicians should stay alert. Furthermore, CLL patients should undergo more frequent screening tests for cancer as compared to the general population.