Real-world work productivity is impaired in people with metabolic dysfunction-associated steatotic liver disease in the USA
Even in its early stages, when otherwise asymptomatic, metabolic dysfunction-associated steatohepatitis (MASH) may impact the ability to work. Using the Work Productivity and Activity Impairment: Specific Health Problem (WPAI:SHP) questionnaire, we identified activity and overall work impairment in people with high- and low-risk MASH. We found a link between difficulty working and other signs, such as tiredness, sleep disturbance, and general weakness, in low-risk MASH that are not specific to MASH but can be associated with liver health. These general, non-specific signs could represent possible early warning signs preceding reduced productivity in patients with MASH.
Authors
- Andrea Leith (ORCID: https://orcid.org/0000-0002-1147-5306)
- Mary Eugenia Rinella (ORCID: https://orcid.org/0000-0003-0620-9705)
- James Pike (ORCID: https://orcid.org/0000-0002-4208-2871)
- Mark L. Hartman (ORCID: https://orcid.org/0000-0003-2396-7356)
- Quentin M. Anstee (ORCID: https://orcid.org/0000-0002-9518-0088)
- Victoria Higgins (ORCID: https://orcid.org/0000-0002-3901-7390)
- David Schapiro (ORCID: https://orcid.org/0000-0002-3083-3615)
- Shraddha Shinde (ORCID: https://orcid.org/0009-0003-0120-7580)
Institutions
- Eli Lilly (United States) (US)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- National Institute for Health and Care Research (GB)
- University of Chicago (US)
- Adelphi Group (United Kingdom) (GB)
- Newcastle University (GB)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101558
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Eli Lilly and Company