In Vitro Activity of Silver-Bound Titanium Dioxide (Tiab) Against Multidrug-Resistant Bacteria from Dermatological Infections

TiAB exhibited in vitro bactericidal activity with median MIC values ranging from 1% to 2% (<i>w</i>/<i>v</i>) against Gram-negative clinical isolates such as <i>E. coli</i> and <i>P. aeruginosa</i>, and 2% to 4% against Gram-positive strains including MRSA. Time-kill assays confirmed ≥3 log₁₀ CFU/mL reductions for Gram-negative bacteria at 2× MIC within 24 h. These results suggest TiAB's potential as a topical antimicrobial agent, though further in vivo studies are needed to validate its safety and efficacy.