Hispanic/Latino ethnic background and genetic ancestry in relation to atherosclerotic cardiovascular disease risk estimation: Findings from the Multi-Ethnic Study of Atherosclerosis (MESA)
Disaggregating Hispanics/Latinos by background and ancestry led to variability in PCE performance with greater overestimation of ASCVD risk for those of Caribbean background and those with increasing quantiles of African genetic ancestry.
Authors
- Robyn L. McClelland (ORCID: https://orcid.org/0000-0002-2433-1512)
- Bede N. Nriagu (ORCID: https://orcid.org/0000-0003-3006-4796)
- Anurag Mehta
- Parag H. Joshi (ORCID: https://orcid.org/0000-0001-7863-2794)
- Amit V. Khera (ORCID: https://orcid.org/0000-0001-6535-5839)
- Tamar Sofer (ORCID: https://orcid.org/0000-0001-8520-8860)
- Carlos J. Rodríguez (ORCID: https://orcid.org/0000-0003-3618-9514)
- Karen Flores Rosario (ORCID: https://orcid.org/0000-0001-6679-6345)
- Spencer Hansen (ORCID: https://orcid.org/0000-0003-0853-4907)
- Robert C. Kaplan (ORCID: https://orcid.org/0000-0003-1571-4615)
- Priscilla Duran Luciano (ORCID: https://orcid.org/0000-0003-4920-2941)
Institutions
- Brigham and Women's Hospital (US)
- Albert Einstein College of Medicine (US)
- Virginia Department of Health (US)
- Harvard University (US)
- Duke University (US)
- University of Washington (US)
- Metropolitan Hospital Center (US)
- Fred Hutch Cancer Center (US)
- Verve Therapeutics (United States) (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- American Journal of Preventive Cardiology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1016/j.ajpc.2025.101268
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Heart, Lung, and Blood Institute
- National Center for Research Resources