Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition
The findings underscore the limited utility of the 4Kscore in improving medium- to longer-term risk prediction over PSA, with potential benefits restricted to younger men with elevated PSA.
Authors
- Georgina K. Fensom (ORCID: https://orcid.org/0000-0003-0979-4436)
- Konstantinos K. Tsilidis (ORCID: https://orcid.org/0000-0002-8452-8472)
- Eleanor L. Watts (ORCID: https://orcid.org/0000-0001-9229-2589)
- Urwah Noor (ORCID: https://orcid.org/0009-0007-3885-5898)
- María‐Dolores Chirlaque (ORCID: https://orcid.org/0000-0001-9242-3040)
- Ruth C. Travis (ORCID: https://orcid.org/0000-0002-9571-0763)
- Rudolf Kaaks (ORCID: https://orcid.org/0000-0003-3751-3929)
- Carlotta Sacerdote (ORCID: https://orcid.org/0000-0002-8008-5096)
- Matthias Bernd Schulze (ORCID: https://orcid.org/0000-0002-0830-5277)
- Rosario Tumino (ORCID: https://orcid.org/0000-0003-2666-414X)
- Karl Smith-Byrne (ORCID: https://orcid.org/0000-0002-1932-7463)
- Sabina Sieri (ORCID: https://orcid.org/0000-0001-5201-172X)
- Timothy J. Key (ORCID: https://orcid.org/0000-0003-2294-307X)
- Domenico Palli (ORCID: https://orcid.org/0000-0002-5558-2437)
- Marcela Guevara (ORCID: https://orcid.org/0000-0001-9242-6364)
- Elio Ríboli (ORCID: https://orcid.org/0000-0001-6795-6080)
- Verena Katzke (ORCID: https://orcid.org/0000-0002-6509-6555)
- Naomi E. Allen (ORCID: https://orcid.org/0000-0003-1938-5038)
- Marc J. Gunter (ORCID: https://orcid.org/0000-0001-5472-6761)
- Marta Crous‐Bou (ORCID: https://orcid.org/0000-0003-1493-4288)
- Pilar Amiano (ORCID: https://orcid.org/0000-0003-3986-7026)
- María‐José Sánchez (ORCID: https://orcid.org/0000-0003-4817-0757)
Institutions
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Harvard University (US)
- Universidad de Granada (ES)
- University of Potsdam (DE)
- German Cancer Research Center (DE)
- University of Ioannina (GR)
- Heidelberg University (DE)
- Prevention Institute (US)
- Bellvitge University Hospital (ES)
- Public Health England (GB)
- University of Oxford (GB)
- Instituto de Salud Pública de Navarra (ES)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Istituto per lo Studio e la Prevenzione Oncologica (IT)
- Biogipuzkoa Health Research Institute (ES)
- Regional Health (US)
- Institut Català d'Oncologia (ES)
- NIHR Imperial Biomedical Research Centre (GB)
- Department of Medical Sciences (RU)
- Navarre Institute of Health Research (ES)
- Instituto de Investigación Biosanitaria de Granada (ES)
- UK Biobank (GB)
- Instituto Murciano de Investigación Biosanitaria (ES)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- German Institute of Human Nutrition (DE)
- Centre international de recherche sur le cancer (FR)
- Imperial College London (GB)
- Andalusian School of Public Health (ES)
- Universidad de Murcia (ES)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Cancer Epidemiology Biomarkers & Prevention
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1158/1055-9965.epi-24-1877
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00