Association of Quinolone Exposure in the First‐Trimester of Pregnancy and the Risk of Major Congenital Malformations: A Health Administrative Database Study in Japan
Prescription of quinolones in the first-trimester of pregnancy was not associated with an increased risk of MCMs in infants. Our findings may support clinical decision-making when considering quinolone use during the first-trimester of pregnancy.
Authors
- Taku Obara (ORCID: https://orcid.org/0000-0002-3674-1674)
- Ryo Obara (ORCID: https://orcid.org/0000-0003-1022-3569)
- Tomofumi Ishikawa (ORCID: https://orcid.org/0000-0002-0901-368X)
- Hiroshi Kawame (ORCID: https://orcid.org/0000-0001-5661-3525)
- Nariyasu Mano (ORCID: https://orcid.org/0000-0003-1679-9024)
- Takamasa Sakai (ORCID: https://orcid.org/0000-0001-9086-6999)
- Noriyuki Iwama (ORCID: https://orcid.org/0000-0002-6808-0911)
- Aoi Noda (ORCID: https://orcid.org/0000-0002-7644-6848)
- Mami Ishikuro (ORCID: https://orcid.org/0000-0002-2884-0023)
- Masatsugu Orui (ORCID: https://orcid.org/0000-0002-4871-8455)
- Shinichi Kuriyama (ORCID: https://orcid.org/0000-0003-2526-2974)
- Genki Shinoda
- Kei Morishita (ORCID: https://orcid.org/0000-0002-0250-2800)
Institutions
- Tohoku University (JP)
- Tohoku University Hospital (JP)
- The Jikei University Hospital (JP)
- Tohoku Medical Megabank Organization (JP)
- Tohoku Medical and Pharmaceutical University (JP)
- Meijo University (JP)
Publication Details
- Journal
- Pharmacoepidemiology and Drug Safety
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1002/pds.70190
- Citations
- 1
- Primary Topic
- Pregnancy and Medication Impact
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Ministry of Health, Labour and Welfare