Limb-girdle muscular dystrophy D3: The first North American family and review of the literature

Limb-girdle muscular dystrophy type D3 is a rare, late-onset muscular dystrophy that has, to date, only been identified in European, South American, and Asian populations. Here we present the index patient of the first North American family with LGMDD3. We review this disorder and highlight both common and uncommon clinical features. We also discuss new insights into disease pathogenesis.