Nanoparticles as Immunomodulator

Nanoparticles are characterized as dispersed or solid particulate having diameter ranges from 1 to1000nm. Since the last few decades hydrophilic polymer coated biodegradable nano-polymer are being applied as prospective drug delivery vehicle. Numerous external and internal atmospheric factors provoke infections in host; which is shielded by normal immune functions. The functions of immune system may perhaps be activated or restrained by certain aspects. The present review article was aimed in searching of a new light on the role of nanoparticle in immunomodulation. During infection, body’s immune resistance is subsidiazed by Immunosuppression. The function of B-cell in alveolar macrophages is repressed by Carbon nanotubes through the production of TGF-β, which is a key reason of immunosuppression. Antigen loaded with nanoparticle provokes the secretion of interferon-γ and IL-4 cytokines in immunological cells. Keywords: Nanoparticle, antigen, immune system, immunomodulation