Hypoxic stem cells from apical papilla-derived exosomes enhance dental pulp stem cells migration and differentiation via mitochondrial activation

Hypoxic SCAPs-derived exosomes enhance DPSCs migration and odontogenic differentiation through mitochondrial fusion. These findings reveal a novel "exosome-mitochondria" regulatory axis, providing a mechanistic basis for developing hypoxia-engineered exosome therapies in dental regenerative medicine.

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Publication Details

Journal
Journal of Dental Sciences
Published
2025-08-14
DOI
https://doi.org/10.1016/j.jds.2025.07.028
Primary Topic
Mesenchymal stem cell research
Type
article
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article

Hypoxic stem cells from apical papilla-derived exosomes enhance dental pulp stem cells migration and differentiation via mitochondrial activation

Yin Bi, Meng Gu, Dongdong Yuan, Rui Tao
Journal of Dental Sciences
Mesenchymal stem cell research
article

Hypoxic stem cells from apical papilla-derived exosomes enhance dental pulp stem cells migration and differentiation via mitochondrial activation

Yin Bi, Meng Gu, Dongdong Yuan, Rui Tao
article en

Abstract

Hypoxic SCAPs-derived exosomes enhance DPSCs migration and odontogenic differentiation through mitochondrial fusion. These findings reveal a novel "exosome-mitochondria" regulatory axis, providing a mechanistic basis for developing hypoxia-engineered exosome therapies in dental regenerative medicine.

Journal of Dental SciencesVol. 21(1)
Stomatology Hospital (CN)
Openalex Percentile: Top 71%
Mesenchymal stem cell research
DOIOpen Access PDFOpenAlex
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Hypoxic stem cells from apical papilla-derived exosomes enhance dental pulp stem cells migration and differentiation via mitochondrial activation — Yin Bi, Meng Gu, et al. · Journal of Dental Sciences (2025) | TGRS Research Map | TGRS