Piezo1-mediated mechanotransduction in cementocytes via protein kinase B and p38 mitogen-activated protein kinase signaling
Our findings demonstrate that Piezo1 functions as a mechanosensor in cementocytes, modulating the expression of osteo/cementogenic genes via the AKT and p38 pathways. This study provides new insight into the molecular mechanisms of cementocyte mechanotransduction and may inform strategies for periodontal regeneration and orthodontic treatment.
Authors
- Satoru Yamada (ORCID: https://orcid.org/0000-0002-1627-305X)
- Shigeki Suzuki (ORCID: https://orcid.org/0000-0003-0888-4050)
- Hiroyuki Tada (ORCID: https://orcid.org/0000-0002-3049-1096)
- Taichi Tenkumo (ORCID: https://orcid.org/0000-0003-2237-1040)
- Eiji Nemoto (ORCID: https://orcid.org/0000-0001-5996-5294)
- Kaixin Xiong
- Kentaro Maruyama
- Yukihiko Sakisaka
- Faisal Muhammad
Institutions
- Okayama University (JP)
- Tohoku University (JP)
- Sichuan University (CN)
- First Affiliated Hospital of Chengdu Medical College (CN)
Publication Details
- Journal
- Journal of Dental Sciences
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1016/j.jds.2025.08.001
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science