Multi-way calibration strategies involving excitation-emission data measurements from drug-modulated fluorescence in CdTe quantum dots and AgInS2 nanocrystals

The unfolded partial least-squares (U-PLS) model was successfully applied for the determination of amlodipine-net analyte signal (NAS) from binary CdTe QDs fluorescence modulation. In contrast, the olmesartan- NAS from ternary AgInS₂ QDs fluorescence modulation did not allow a combined calibration. Consequently, the analytes must be individually calibrated based on their respective individual mixture signals using either PARAllel FACtor (PARAFAC) analysis or multivariate curve resolution - alternating least-squares (MCR-ALS) model according to the data structure.