Recent advances and applications of miniaturized analytical- and on-line sample preparation- columns

• Current miniaturized column technology was presented and discussed. • Recent advances and applications for trap columns were reviewed. • The most recent achievements based on miniaturized LC were discussed. • Recent CE/CEC applications were presented. • Applications of MIP columns were reviewed. Miniaturized columns are chromatographic columns used in modern LC applications, which are in narrow diameter format while CE/CEC separations with miniaturized columns show high separation efficiency due to flat flow profile from EOF. There are several variants of miniaturized columns with both analytical- and trap columns. This review summarizes and discusses recent advances and applications on miniaturized analytical- and on-line sample preparation- columns focussing on literature mostly between 2019 and 2024.