Intravenous Arginine Stimulates Glucagon Secretion More Than Equimolar Alanine, Leucine, Glutamine, and Proline in Humans
In the given experimental setting, arginine was identified as the most efficient stimulator of glucagon secretion. Arginine, alanine, and glutamine stimulated insulin secretion, with arginine eliciting the largest response. Our results indicate that arginine could be involved in regulating the liver-α cell axis in humans.
Authors
- Malte P. Suppli (ORCID: https://orcid.org/0000-0002-8816-6472)
- Trisha Jean Grevengoed (ORCID: https://orcid.org/0000-0003-4433-3950)
- Julie Lyng Forman (ORCID: https://orcid.org/0000-0001-7368-0869)
- Magnus F.G. Grøndahl (ORCID: https://orcid.org/0000-0001-6475-765X)
- Jonatan I. Bagger (ORCID: https://orcid.org/0000-0003-3174-1613)
- Mikkel Christensen (ORCID: https://orcid.org/0000-0002-8774-1797)
- Asger Lund (ORCID: https://orcid.org/0000-0003-1212-3764)
- A Vranesević
- Samuel A.J. Trammell (ORCID: https://orcid.org/0000-0002-5941-4094)
- Filip K. Knop (ORCID: https://orcid.org/0000-0002-2495-5034)
- Hendrik Vilstrup
- Jens Juul Holst (ORCID: https://orcid.org/0000-0001-6853-3805)
- Astrid Høgedal
- Nicolai J Wewer Albrechtsen (ORCID: https://orcid.org/0000-0003-2730-6301)
Institutions
- University of Copenhagen (DK)
- Steno Diabetes Centers (DK)
- Novo Nordisk (Denmark) (DK)
- Aarhus University (DK)
- Novo Nordisk Foundation (DK)
- Bispebjerg Hospital (DK)
- Aarhus University Hospital (DK)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Novo Nordisk (United States) (US)
Publication Details
- Journal
- Journal of the Endocrine Society
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1210/jendso/bvaf139
- Citations
- 1
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Novo Nordisk
- A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal
- Novo Nordisk Fonden