Protein Kinase D1 (PRKD1) as a Diagnostic, Prognostic, and Immunomodulatory Biomarker in Human Cancers
PRKD1 serves as a potential diagnostic biomarker in BLCA, KICH, and READ, and as a prognostic indicator in STAD, THCA, LIHC, and KIRC. Its expression is modulated by epigenetic mechanisms and correlates with immune cell infiltration, underscoring its relevance in tumor immunobiology and potential as a therapeutic target.
Authors
- Mohamed Alfaki (ORCID: https://orcid.org/0000-0003-4913-2357)
- Nabila Issa Youssouf
- Mariam Abubaker (ORCID: https://orcid.org/0000-0003-0459-3440)
- Khansa Ali
- Ruba Abdelrazig
- Salah A Alshikh
- Samah Mustafa Mohammedosman
Institutions
- University of Khartoum (SD)
- Al-Neelain University (SD)
- International University of Africa (SD)
- University of Kordofan (SD)
- University of Gezira (SD)
- Red Sea University (SD)
Publication Details
- Journal
- Cureus
- Published
- 2025-08-22
- DOI
- https://doi.org/10.7759/cureus.90765
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52