Rhodium(III)-Catalyzed C–H Activation/Annulation of Indoles with Cyclopropanols: A Rapid Assembly of Indole-Fused Diazepinones
The facile synthesis of indole-fused diazepinones via Rh(III)-catalyzed [4 + 3] annulation of indole derivatives with cyclopropyl alcohol by merging sequential C-H and C-C bond cleavage has been realized. Notably, the eight-membered diazocino[7,8,1-<i>hi</i>]indol-5-ones and seven-membered azepino[3,4-<i>b</i>]indol-1(2<i>H</i>)-ones could also be obtained via this tandem reaction strategy. This catalytic approach features mild reaction conditions, readily accessible starting materials, valuable products, and excellent atom-economy.
Authors
- Zhao‐Qing Liu (ORCID: https://orcid.org/0000-0002-0727-7809)
- Feng Feng (ORCID: https://orcid.org/0000-0003-3608-1108)
- Fei-Hong Ouyang
- Liyao Zheng (ORCID: https://orcid.org/0000-0002-1996-7727)
- Jidan Liu (ORCID: https://orcid.org/0000-0001-6469-8100)
- Ran Liang (ORCID: https://orcid.org/0000-0001-9858-7361)
Institutions
- Guangzhou University (CN)
- Clean Energy (United States) (US)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1021/acs.orglett.5c03198
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Guangzhou University
- Basic and Applied Basic Research Foundation of Guangdong Province