The natural statin α,β-dehydromonacolin K exerts anti-secretory effect in human intestinal epithelial cells via a nonsense-mediated mRNA decay-dependent mechanism
α, β-Dehydromonacolin K represents a promising class of natural compounds that exert antisecretory effects in human intestinal epithelia <i>via</i> a novel mechanism of action involving SMG1 in NMD pathways.
Authors
- Wararat Chiangjong (ORCID: https://orcid.org/0000-0002-2984-3330)
- Rungtiwa Khumjiang
- Chatchai Muanprasat (ORCID: https://orcid.org/0000-0001-6849-6637)
- Saravut Satitsri (ORCID: https://orcid.org/0000-0002-1555-4917)
- Vatcharin Rukachaisirikul (ORCID: https://orcid.org/0000-0003-1517-1526)
- Chittreeya Tansakul (ORCID: https://orcid.org/0000-0003-3002-7215)
- Yanisa Purintrapibal
- Taya Kitiyakara
- Nuttapon Apichaiyarat
Institutions
- Prince of Songkla University (TH)
- Mahidol University (TH)
- Ramathibodi Hospital (TH)
Publication Details
- Journal
- Pharmaceutical Biology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1080/13880209.2025.2544930
- Primary Topic
- ATP Synthase and ATPases Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Mahidol University