Factors Affecting the Incidence of Recurrences and Complications of Peptic Ulcer Disease

Aim: to analyze risk factors for relapses and complications of peptic ulcer disease in a cohort of patients. Materials and methods. Retrospective analysis of hospital records of 253 patients (average age — 52.1 ± 8.2 years) with peptic ulcer disease in the acute stage. Patients were stratified by gender, age and anamnestic risk factors, the phenotype of peptic ulcer disease being stratified by etiology, endoscopic characteristics of ulcerative defects of the gastric mucosa and duodenum. Results. The proportion of complicated forms of peptic ulcer disease varies depending on gender, age and ulcer localization. The total number of complications in the cohort is 38.3 %, men developing complications in every second case (47.9 %). Among complications, bleeding is the most common one and accounts for 52.6 %, 42.9 % and 41.2 % of all complications in duodenal, simultaneous and gastric ulcers correspondingly. Cicatricial and ulcerative deformations are associated with localization in the duodenum and combined location of ulcerative defects, the complication being recorded in men 2 times more often than in women. Perforations of gastric ulcer are associated with the male gender (3 times more often). Stenosis is a rare complication, predominantly in women with duodenal ulcer. Significant predictors of complications of peptic ulcer disease are male gender and smoking. Factors associated with the manifestation of peptic ulcer disease include H. pylori and smoking in men, and H. pylori , nonsteroidal anti-inflammatory drugs or combination of these factors in women. Conclusions. The factors influencing the incidence of complications and recurrences of peptic ulcer disease in the hospital cohort have been established: male gender, age of 36–59 years, H. pylori infection, tobacco smoking, NSAID use and simultaneous exposure to several factors in one individual.