Psychosocial Challenges of Parents of Children Undergoing Chemotherapy: A Systematic Review

Context: Childhood cancer constitutes a significant health challenge, profoundly affecting families and placing substantial psychological and social burdens on parents who assume the role of primary caregivers. Objectives: The present systematic review examines the psychosocial challenges faced by parents of children undergoing chemotherapy, using evidence from 16 studies published between 2010 and 2025. Methods: This review combines 16 of the 99 eligible articles published between January 2010 and March 2025. A comprehensive search was conducted across five databases: PubMed, Scopus, Web of Science, Google Scholar, and SID, utilizing predetermined keywords. Study selection focused on relevance to the psychosocial experiences of these parents. Two independent reviewers carried out data extraction. The methodological quality of included studies was assessed using the Cochrane risk of bias tool, Newcastle-Ottawa Scale, and CASP checklist. Both quantitative and qualitative data were analyzed using a thematic synthesis approach. Results: Parents frequently report a range of psychological difficulties, such as ongoing stress, guilt, sleep disturbances, and reduced quality of life. Social challenges, including diminished support systems, financial strain, and conflicts related to managing work and family obligations, are also prevalent. Conclusions: The results underscore the critical need for specialized psychosocial interventions and improved structural support for families confronting childhood cancer. Establishing comprehensive support services within pediatric oncology settings is vital to reducing parental psychosocial burden and improving the overall standard of care for children diagnosed with cancer.