Mortality after colorectal cancer among survivors of childhood cancer
Mortality after diagnosis of colorectal subsequent malignant neoplasms (CRC-SMN) among childhood cancer survivors is understudied. Using data from the Childhood Cancer Survivor Study (CCSS) and the Surveillance, Epidemiology, and End Results (SEER) program, we compared all-cause mortality of survivors with CRC-SMN with survivors without CRC-SMN and CRC patients in the general population without a childhood cancer history. Among 25 656 childhood cancer survivors, 96 developed CRC-SMN, with 50% diagnosed before age 40 years and 19% before age 30 years. Of those diagnosed before age 40 years, 35% had no prior abdominal- or pelvic-directed radiation therapy. The cumulative incidence of CRC-SMN in CCSS survivors was 0.7% (95% CI = 0.5% to 0.9%) by age 45 years and 1.1% (95% CI = 0.8% to 1.4%) by age 50 years. There were 31 deaths after CRC-SMN. Adjusted all-cause mortality was threefold higher (hazard ratio [HR] = 3.34, 95% CI = 2.25 to 4.59) than for survivors without CRC and statistically significantly higher for survivors diagnosed younger than age 30 years compared with SEER CRC patients (HR = 2.51, 95% CI = 1.29 to 4.89).
Authors
- Lucie M. Turcotte (ORCID: https://orcid.org/0000-0003-4106-6172)
- Yutaka Yasui (ORCID: https://orcid.org/0000-0002-7717-8638)
- Greg Armstrong (ORCID: https://orcid.org/0000-0002-3393-7954)
- Rebecca M. Howell (ORCID: https://orcid.org/0000-0002-0803-071X)
- Joanne F. Chou (ORCID: https://orcid.org/0000-0002-6866-2022)
- Paul Craig Nathan (ORCID: https://orcid.org/0000-0003-0334-0871)
- David M. Hodgson (ORCID: https://orcid.org/0000-0001-7201-9841)
- Helen Lam (ORCID: https://orcid.org/0000-0002-3369-8658)
- Wendy M. Leisenring (ORCID: https://orcid.org/0000-0001-7405-0906)
- Ajay Major (ORCID: https://orcid.org/0000-0001-7261-1335)
- Karen Kim (ORCID: https://orcid.org/0000-0003-3466-5353)
- Chaya S. Moskowitz (ORCID: https://orcid.org/0000-0002-2850-8450)
- Kevin Charles Oeffinger (ORCID: https://orcid.org/0000-0003-0806-7894)
- Joseph P. Neglia (ORCID: https://orcid.org/0000-0002-5525-0598)
- Tara Olive Henderson (ORCID: https://orcid.org/0000-0001-9394-6206)
- Michael Curry (ORCID: https://orcid.org/0000-0002-0261-4044)
Institutions
- Lurie Children's Hospital (US)
- University of Minnesota (US)
- St. Jude Children's Research Hospital (US)
- Memorial Sloan Kettering Cancer Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Duke University (US)
- Hospital for Sick Children (CA)
- Princess Margaret Cancer Centre (CA)
- Fred Hutch Cancer Center (US)
- Lurie Children's Hospital (US)
- Comer Children's Hospital (US)
- Penn State Milton S. Hershey Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1093/jnci/djaf127
- Primary Topic
- Childhood Cancer Survivors' Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 0.00