Mitochondrial calcium uniporter promotes MSU crystal-induced inflammation through inducing mitochondrial Ca2+ overload and ubiquitination of SIRT5 protein
Our findings demonstrate that MCU drives mitochondrial Ca²⁺ overload in MSU crystal-induced inflammation and promotes SIRT5 degradation via the TRIM21-SIRT5 signaling axis. These insights highlight MCU as a potential therapeutic target in gouty inflammation.
Authors
- Qian Dai (ORCID: https://orcid.org/0000-0002-5774-7469)
- Mei Zeng (ORCID: https://orcid.org/0000-0002-5661-7101)
- Yan Xiao (ORCID: https://orcid.org/0000-0003-4242-6387)
- Xiongyan Luo
- Renjie Li (ORCID: https://orcid.org/0000-0002-3425-6560)
- Guojian Yang (ORCID: https://orcid.org/0000-0001-5403-1855)
- Xingyu Liu (ORCID: https://orcid.org/0009-0007-3194-9496)
- Yaxin Deng (ORCID: https://orcid.org/0009-0005-7945-0120)
- Qingqing Yu
Institutions
- North Sichuan Medical University (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1186/s13075-025-03627-3
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China