Cyclooxygenase-1 deletion in 5 × FAD mice protects against microglia-induced neuroinflammation and mitigates cognitive impairment
Our findings indicate that targeting the COX-1/PGE2/EP2 signaling pathway may alleviate neuroinflammation and impede AD progression. Moreover, the EP2 receptor presents a promising pharmacological target for mitigating the pathological effects associated with COX-1 activity in AD patients.
Authors
- Deheng Wang (ORCID: https://orcid.org/0000-0001-7979-9756)
- Zhongzhao Guo (ORCID: https://orcid.org/0000-0003-1337-9729)
- Hanqing Ding (ORCID: https://orcid.org/0000-0003-0795-6585)
- Jia Luo (ORCID: https://orcid.org/0000-0002-6968-3618)
- Weidong Pan (ORCID: https://orcid.org/0000-0002-0380-4210)
- Hao Pan
- Zunji Ke (ORCID: https://orcid.org/0000-0003-4038-2456)
- Hong Ni (ORCID: https://orcid.org/0000-0002-0974-6410)
- Luyao Wei
- Ying Yu (ORCID: https://orcid.org/0000-0002-6476-1752)
- Jie Wang (ORCID: https://orcid.org/0000-0003-4338-2873)
- Yu Wang (ORCID: https://orcid.org/0009-0005-7281-3734)
Institutions
- University of Iowa (US)
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Zhongshan Hospital (CN)
- Yueyang Hospital (CN)
- Shuguang Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Translational Neurodegeneration
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1186/s40035-025-00501-9
- Citations
- 5
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 4.21
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality