U-shaped relationship between the triglyceride glucose index and the risk of incident diabetes among MASLD adults: a retrospective cohort study
A U-shaped association was identified between baseline TyG-i and the incidence of T2D in a Japanese population with MASLD. This inflection point in TyG-i serves as a valuable clinical indicator to differentiate individuals at lower versus higher risk of developing T2D. These findings indicate that maintaining TyG-i near the inflection point may be beneficial in reducing the risk of developing diabetes in patients with MASLD.
Authors
- Changchun Cao (ORCID: https://orcid.org/0000-0003-1992-4257)
- Haofei Hu (ORCID: https://orcid.org/0000-0001-6061-6796)
- Yong Han (ORCID: https://orcid.org/0000-0001-6149-3724)
- Xiao‐Hua Zhang (ORCID: https://orcid.org/0000-0002-7428-7775)
- Yulong Wang (ORCID: https://orcid.org/0000-0002-0947-6967)
Institutions
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.3389/fendo.2025.1516187
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Sanming Project of Medicine in Shenzhen