Lactate modulates the function of myeloid-derived suppressor cells via Ten-Eleven-Translocation-2-mediated demethylation of glucocorticoid-inducible kinase 1 in lung cancer model
Lactate can upregulate the expression of SGK1 through demethylation mediated by TET2, enhancing the immunosuppressive function of MDSCs to promote tumor progression. It provides the effective therapeutic targets for anti-tumor therapy.
Authors
- Shengjun Wang (ORCID: https://orcid.org/0000-0001-6584-1183)
- Jie Ma (ORCID: https://orcid.org/0000-0003-3776-4429)
- Qiu Li (ORCID: https://orcid.org/0000-0002-5299-9050)
- Wei Zhu
- Hua Shen (ORCID: https://orcid.org/0000-0002-4928-525X)
- Deqiang Wang (ORCID: https://orcid.org/0000-0002-8411-312X)
- Ying Chu (ORCID: https://orcid.org/0000-0003-1144-6297)
- Bo Shen (ORCID: https://orcid.org/0000-0002-8782-3151)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-4835-8541)
Institutions
- Jiangsu University (CN)
- Affiliated Hospital of Jiangsu University (CN)
- Jiangsu Cancer Hospital (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.3389/fcell.2025.1565993
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80