Organelle stresses and energetic metabolisms promote endothelial–to–mesenchymal transition and fibrosis via upregulating FOSB and MEOX1 in Alzheimer’s disease
This study uncovers previously unrecognized molecular signatures of organelle stress and bioenergetic reprogramming that drive EndoMT, cell death, and fibrosis in AD. The reversal of these changes via PERK, FOSB, and MEOX1 inhibition highlights potential therapeutic targets for mitigating neurodegenerative processes in AD.
Authors
- Silvia Fossati (ORCID: https://orcid.org/0000-0002-2047-222X)
- Fatma Saaoud
- Laisel Martinez (ORCID: https://orcid.org/0000-0002-3009-8761)
- Xiaohua Jiang (ORCID: https://orcid.org/0009-0006-9812-9145)
- Hong Wang (ORCID: https://orcid.org/0000-0003-0165-3559)
- Keman Xu (ORCID: https://orcid.org/0000-0002-0816-1760)
- Beata Kośmider (ORCID: https://orcid.org/0000-0001-7421-5424)
- Avrum Gillespie (ORCID: https://orcid.org/0000-0002-7528-5800)
- Xiaofeng Yang (ORCID: https://orcid.org/0000-0001-6143-5209)
- Sadia Mohsin
- Roberto I. Vázquez-Padrón (ORCID: https://orcid.org/0000-0002-9370-276X)
- Jin Jun Luo (ORCID: https://orcid.org/0000-0001-9883-0763)
- Xiaolei Liu (ORCID: https://orcid.org/0000-0002-6881-3716)
- Yifan Lu (ORCID: https://orcid.org/0000-0003-4461-0698)
- Ying Shao (ORCID: https://orcid.org/0000-0003-0033-4820)
- Baosheng Han
- M. Issa
- Lu Liu (ORCID: https://orcid.org/0009-0008-7393-4329)
Institutions
- University of Miami (US)
- Temple University (US)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2025-08-22
- DOI
- https://doi.org/10.3389/fnmol.2025.1605012
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16