Exploring the protective mechanisms of the yunpi jiedu tongluo qushi decoction on methotrexate-induced reproductive damage in male rats based on Nrf2/HO-1 signaling pathway
Collectively, our findings indicate that YJT protects against MTX-induced apoptosis in spermatogenic cells by inhibiting OS and Nrf2/HO-1 signaling pathway. This study provides a theoretical foundation and experimental basis for the use of YJT to alleviate MTX-induced reproductive toxicity.
Authors
- Chengping Wen (ORCID: https://orcid.org/0000-0001-9254-6235)
- Dianming Li (ORCID: https://orcid.org/0000-0002-1279-1319)
- Lin Huang (ORCID: https://orcid.org/0000-0002-8036-8408)
- Chen Wu (ORCID: https://orcid.org/0000-0002-0672-2122)
- Zhiyu Li (ORCID: https://orcid.org/0000-0001-6492-9511)
- Qiao Wang (ORCID: https://orcid.org/0000-0003-0648-9399)
- Min Chen (ORCID: https://orcid.org/0000-0003-0419-743X)
- Min Zhang (ORCID: https://orcid.org/0000-0002-4399-0425)
- Weiman Shi
Institutions
- Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.3389/fcell.2025.1626955
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00