Tooth loss impairs cognitive function in SAMP8 mice by aggravating pyroptosis of microglia via the cGAS/STING pathway
These data suggest that the occlusal support loss due to tooth loss induces pyroptosis-related protein deposition, which may be intimately associated with the cGAS/STING signaling pathway. This provides new insights into the treatment and prevention of oral health and cognitive behavioural disorders in the elderly population.
Authors
- Qingsong Jiang (ORCID: https://orcid.org/0000-0003-1886-6323)
- Jiangqi Hu (ORCID: https://orcid.org/0000-0003-1160-3942)
- Yunping Lu
- Xiaoyu Wang (ORCID: https://orcid.org/0000-0002-5198-5108)
- Xu Sun
- Shixiang Meng
Institutions
- Capital Medical University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-08-22
- DOI
- https://doi.org/10.3389/fnagi.2025.1628520
- Citations
- 2
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China