Colonoscopic fecal microbiota transplantation for Mild-to-Moderate Parkinson’s Disease: A randomized controlled trial
Fresh FMT via colonoscopy is a safe and well-tolerated procedure for treating mild-to-moderate PD. It effectively alleviates motor and non-motor symptoms, thus facilitating defecation and improving the quality of life. These effects can be maintained for a minimum of 12 weeks and may be attributed to the optimization of gut microbiota and fecal metabolites.
Authors
- Shang-Nong Wu (ORCID: https://orcid.org/0000-0001-8843-8215)
- Xiaozhong Yang (ORCID: https://orcid.org/0000-0002-4887-5602)
- Liujun Xue
- Qiang Tong (ORCID: https://orcid.org/0000-0002-1259-7348)
- Weijie Dai (ORCID: https://orcid.org/0000-0001-5798-5750)
- Minna Zhang (ORCID: https://orcid.org/0000-0003-1567-3788)
- Jingyi Wang (ORCID: https://orcid.org/0000-0003-0465-6253)
- Wenzhuo Zhao
- Peng Shen (ORCID: https://orcid.org/0000-0002-3765-2630)
- Honggang Wang (ORCID: https://orcid.org/0000-0003-4761-0407)
Institutions
- Huaian First People’s Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1016/j.bbi.2025.106086
- Citations
- 3
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.17