Transcriptomic profiling of Sjögren’s disease salivary glands identifies signatures associated with both follicular and extrafollicular responses linked to rheumatoid factor and anti-La/SSB seropositivity
Comprehensive SG bulk-RNA sequencing provided the first transcriptomic evidence of distinct RF and anti-La/SSB-driven SG transcriptomic signatures in patients with SjD with and without ELS. These findings suggest that both classical follicular and extrafollicular viral-associated responses contribute to the selection of autoreactive B-cells in the glands of patients with SjD.
Authors
- Ling‐Yang Hao
- Davide Lucchesi (ORCID: https://orcid.org/0000-0002-8019-556X)
- Elena Pontarini (ORCID: https://orcid.org/0000-0003-0439-0344)
- Nurhan Sutcliffe (ORCID: https://orcid.org/0000-0002-8150-6446)
- Giulia Cavallaro (ORCID: https://orcid.org/0009-0000-1212-8368)
- Anwar R. Tappuni (ORCID: https://orcid.org/0000-0002-5370-2423)
- Kathy L. Sivils
- Elisabetta Sciacca (ORCID: https://orcid.org/0000-0001-7525-1558)
- Annalisa Marino (ORCID: https://orcid.org/0000-0002-2511-7374)
- Simon Bowman (ORCID: https://orcid.org/0000-0001-9880-9948)
- Roberto Giacomelli (ORCID: https://orcid.org/0000-0003-0670-9638)
- Myles Lewis (ORCID: https://orcid.org/0000-0001-9365-5345)
- Alfredo Pulvirenti (ORCID: https://orcid.org/0000-0002-9764-0295)
- Costantino Pitzalis (ORCID: https://orcid.org/0000-0003-1326-5051)
- Qingxuan Song
- David W. Galbraith (ORCID: https://orcid.org/0000-0003-4020-1635)
- Stefano Bombardieri (ORCID: https://orcid.org/0000-0002-3878-5216)
- E Thomas
Institutions
- University Hospitals Birmingham NHS Foundation Trust (GB)
- Janssen (Belgium) (BE)
- Università Campus Bio-Medico (IT)
- Queen Mary University of London (GB)
- Barts Health NHS Trust (GB)
- University of Catania (IT)
- Springhouse (US)
- Istituto per il Sistema Produzione Animale in Ambiente Mediterraneo (IT)
- William Harvey Research Institute (GB)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1016/j.ard.2025.07.021
- Citations
- 6
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 6.99
Funders
- William Harvey Research Foundation
- Medical Research Council