Proteomic profiling identifies a stromal TGF-β1/podoplanin axis as a driver of colorectal cancer progression
This study reveals a novel mechanism by which the TME facilitates CRC progression and highlights PDPN as a potential prognostic biomarker and therapeutic target in CRC.
Authors
- Marco Gaspari (ORCID: https://orcid.org/0000-0002-5411-8800)
- Vittorio Abbonante (ORCID: https://orcid.org/0000-0001-8066-9895)
- Giovanni Cuda (ORCID: https://orcid.org/0000-0001-6313-1866)
- Giuseppe Currò (ORCID: https://orcid.org/0000-0001-9566-1378)
- Caterina Gabriele
- Vittoria Rago (ORCID: https://orcid.org/0000-0003-3971-7378)
- Silvia Di Agostino (ORCID: https://orcid.org/0000-0003-3730-1125)
- Francesco Conforti (ORCID: https://orcid.org/0009-0001-1835-6078)
- Valeria Zuccalà (ORCID: https://orcid.org/0000-0003-3478-9217)
- Girolamo Ranieri (ORCID: https://orcid.org/0000-0002-7952-694X)
- Elvira Immacolata Parrotta (ORCID: https://orcid.org/0000-0001-8145-3623)
- Angela Alibrandi (ORCID: https://orcid.org/0000-0001-6695-151X)
- Davide La Padula
- Andrea Sacconi (ORCID: https://orcid.org/0000-0002-8276-0438)
- Danilo Lofaro (ORCID: https://orcid.org/0000-0002-2081-463X)
- Lidia Urlandini
- Valeria Cernaro
- Francesca Vescio
- Michele Ammendola
- Elio Aprigliano
Institutions
- University of Messina (IT)
- Magna Graecia University (IT)
- Istituto Tumori Bari (IT)
- Ospedale Annunziata di Cosenza (IT)
- University of Calabria (IT)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1186/s13046-025-03496-3
- Citations
- 1
- Primary Topic
- Lymphatic System and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Ministero dell'Università e della Ricerca