From metabolomics to transfusion-associated immunomodulation
Metabolomics has transformed our understanding of TRIM, emphasizing that transfusion is an active biochemical intervention rather than passive fluid replacement. Moving forward, integrating metabolomic insights into transfusion medicine promises personalized strategies - selecting blood units based on metabolic rather than chronological age and donor characteristics - thus improving safety and clinical outcomes in transfusion recipients.
Authors
- James C. Zimring (ORCID: https://orcid.org/0000-0002-1063-4010)
- Angelo D’Alessandro (ORCID: https://orcid.org/0000-0002-2258-6490)
Institutions
- University of Virginia (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Current Opinion in Immunology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1016/j.coi.2025.102646
- Citations
- 1
- Primary Topic
- Neuroscience of respiration and sleep
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- National Heart, Lung, and Blood Institute
- NHLBI Division of Intramural Research